ORGANOPHOSPHORUS POISONING THESIS

Mortality is directly proportionate to the severity of poisoning, delay in starting PAM and duration of mechanical ventilation. During the study period, patients reported to the A and E with history of acute OP poisoning, of whom 8 patients were brought dead to the A and E, 16 patients were referred to other hospitals due to non-availability of beds and ventilators in the ICU and 93 patients were admitted to the ICU. A review of the evidence in India; pp. Most patients with intermediate syndrome develop respiratory failure, which requires mechanical ventilation. In addition, hemoperfusion cannot guarantee blood temperature of extracorporeal circulation, so blood coagulation often occurs in the perfusion device. The severity of poisoning was graded according to Dreisbach’s classification [ Appendix 1 ].

The fatal issue is often related to a delay in diagnosis or an improper management. J Toxicol Clin Toxicol. Most patients with intermediate syndrome develop respiratory failure, which requires mechanical ventilation. Clin Toxicol Phila ; The treatment group comprised 34 patients, including 18 male and 16 female patients. However, there are some limitations about hemoperfusion and hemodialysis treatment:

Hemodialysis technique can fully eliminate poisons with small molecular weight, low lipid solubility, and bonding rate with proteins depending on diffusion and ultrafiltration effects.

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Patients who received hemoperfusion and hemodialysis were included into the observation group, whereas patients who refused these treatments were included into the control group.

Discussion Studies [ 67 ] have reported that hemoperfusion and hemodialysis on the basis of routine treatment for organophosphorus pesticide poisoning could increase the success rate of rescue, and improve the prognosis of patients. Factors for determining survival in acute organophosphate poisoning.

organophosphorus poisoning thesis

The age organoophosphorus these patients ranged within 18 to 66 years, with an average age of Data were analyzed using SPSS Author information Copyright and License information Disclaimer. Introduction Organophosphorus pesticide is an agricultural pesticide that is tbesis used in China, and its dosage reaches the maximum among other pesticides. In A and E, treatment was started as per the protocol for managing OP poisoning patients in our hospital.

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Multivariate binary logistic regression analysis was done with death as the dependent variable and age, lag time to PAM therapy, severity of poisoning and duration of ventilation as the covariates.

organophosphorus poisoning thesis

Correlation between lag period of starting of PAM and duration of mechanical ventilation. However, in this study, the observation group adopts hemoperfusion combined with hemodialysis treatment. Direct puncture of the femoral vein and median cubital vein, or dual-lumen femoral vein catheterization were thesos to establish an effective temporary vascular access.

Therefore, hemoperfusion combined with hemodialysis is often used in clinical practices to treat patients with organophosphorus pesticide poisoning.

Articles from Medicine are provided here courtesy of Wolters Kluwer Health. J Pak Med Assoc. A clinical research of curing heavily organophosphorus pesticide toxicosis by hemoperfusion combined with discount. The Chi-square test was used to analyse the non-parametric data.

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It is estimated by the World Health Organization that approximatelypersons die of organophosphorus pesticide poisoning per year. Studies [ 67 ] have reported that hemoperfusion and hemodialysis on the basis of routine treatment for organophosphorus pesticide poisoning could increase the success rate of rescue, and improve the prognosis of patients.

Patients develop vascular spasm and tissue hypoxia and ischemia induced by a large amount of ACh, which result in the release of a large number of inflammatory mediators, and leads to multiple organ dysfunction syndrome and microcirculation disorder. There is no single study to our knowledge describing the average dose of PAM per patient.

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This article has been cited by other articles in PMC. Atropine was subsequently replaced by glycopyrolate, the dose of which was progressively decreased. Abstract Background and Aims: The control group comprised 34 patients, including 17 male and 17 female patients.

Chin Crit Care Med ; 4: An illustrative case of mixed pesticide poisoning with remarkable improvement: This incidence of suicidal poisoning is much higher than the recorded range of Respiratory failure tthesis acute organophosphate and carbamate poisoning.

The average dose of PAM required per tesis was From hospitalization on, atropinization time, recovery time of cholinesterase activity, recovery time of consciousness, extubation time, length of hospital stay, mortality, poisoning rebound rate, and the success rate of rescue were recorded in detail. Administration of PAM and atropine was continued till the target end point was reached. Department of Anaesthesiology, J.

Self poisoning with pesticides. Multivariate binary logistic regression analysis was done with death as the dependent variable and age, lag time to PAM therapy, severity of poisoning and duration of ventilation as the covariates.

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