ORGANOPHOSPHORUS POISONING THESIS

Health implications from monocrotophos use: The differences between these 2 groups were statistically significant. Though the odds of death due to OP poisoning given presence of age, lag time, severity of poisoning and duration of mechanical ventilation were statistically insignificant, but the odds ratio OR more than 1 in all these cases show exposure associated with higher odds of outcome [ Table 5 ]. Written informed consent was obtained from all participants. This study reports the clinical emergency treatment of 68 critical patients with severe organophosphorus poisoning, and analyzes the prognosis after rescue. Organophosphorus poisoning in Kashmir Valley.

The treatment group comprised 34 patients, including 18 male and 16 female patients. Bikramjit Das Department of Anaesthesiology, J. Clin Toxicol Phila ; They concluded that further RCTs are required to examine other strategies and regimens. Atropine combined with pralidoxime treatment was additionally given: Abu Nadeem Department of Anaesthesiology, J.

Frequency of post-treatment complications of both groups Thirty-four patients received hemodialysis and hemoperfusion for times, and 25 patients had complications.

organophosphorus poisoning thesis

In this study, the cholinesterase levels were not organophosphoruw due to non-availability of the facility. It is estimated by the World Health Organization that approximatelypersons die of organophosphorus pesticide poisoning per year. Initial management of all patients with pralidoxime PAM and atropine were done as per the recommended dosage schedule.

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Guide China Med Stomach thesia was carried out poisoinng all patients with nasogastric tubes; Li et al. The age of these patients ranged within 18 to 66 years, with an average age of Discussion Studies [ 67 ] have reported that hemoperfusion and hemodialysis on the basis of routine treatment for organophosphorus pesticide poisoning could increase the success rate of rescue, and improve the prognosis of patients.

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Types of poisoning include Dipterex poisoning in 14 patients, methyl parathion poisoning in 10 patients, methamidophos poisoning in 5 patients, and dichlorvos poisoning in 5 patients.

It is estimated by the World Health Organization that approximatelypersons die of organophosphorus pesticide poisoning per year. The differences between these 2 groups were statistically significant.

Mortality from OP compound poisoning is directly proportionate to the severity of poisoning, delay in starting PAM, and duration of mechanical ventilation.

Thesis details | Ciências Farmacêuticas

However, in this study, the observation group adopts hemoperfusion combined with hemodialysis treatment. Patients in the control group received routine emergency treatment, including gastrolavage, catharsis, rehydration, maintenance of water-electrolyte balance, and anti-infection treatment. In the present study, the incidence was highest in patients aged less than 40 years.

J Assoc Physicians India. Although it works at nicotinic, muscarinic, and central nervous system receptors, its main therapeutic effect is predicted to be the recovery of neuromuscular transmission at nicotinic synapses. The people in this age group are described to be most ambitious, productive and responsible. Cholinesterase inhibitor pesticides; pp.

organophosphofus

organophosphorus poisoning thesis

Most of the patients received PAM within hours of poisoning and required mechanical ventilation for days. Acute organopshophorous poisoning in Srilanka.

As per the case file of the patients, the diagnosis was made on the basis of history of exposure or contact and characteristic clinical picture. Data were organophosphlrus using SPSS The age of these patients ranged within 18 to 66 years, with an average age of For patients with severe arrhythmia, toxic encephalopathy, cerebral edema, and cerebral hernia, symptomatic treatments should be given and life support should be strengthened.

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OP compounds are used worldwide in agriculture as well as in household gardens. These patients are prone to develop respiratory failure for many reasons, and multiple mechanisms including aspiration of gastric contents, excessive secretions, thoracic weakness, decreased respiratory drive, pneumonia and sepsis-complicating ARDS.

In summary, this study verifies that hemoperfusion and hemodialysis on the basis of routine treatment can improve the success rate of clinical rescue, and improve the prognosis of patients, which is worthy of clinical popularization and application for treating organophosphorus pesticides poisoning patients with renal insufficiency.

Organlphosphorus severity of poisoning was graded according to Dreisbach’s classification [ Appendix 1 ]. Senanayake N, Karaliedde L. Among the 34 patients in the control group, there are 4 cases with renal failure Acute organophosphorus pesticide poisoning can cause consciousness disorders.

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PAM in the dose of 1 g IV infusion over a period of hrs was continued until fasciculations disappeared or skeletal muscle weakness was relieved. Therefore, it is unable to correct water and electrolyte disturbance and acid—base imbalance. Lethality of suicidal organophosphorus organpphosphorus in an Indian population:

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